医学
生长激素缺乏
冲程(发动机)
体质指数
激素
内科学
催乳素
儿科
垂体机能减退
内分泌系统
生长激素
机械工程
工程类
作者
Lisa A. Kreber,Mark J. Ashley,Brent E. Masel,Charan Singh,Kevin D Randle,Christine Johnson,Richard Helvie,Matthew J. Ashley,Grace S. Griesbach
出处
期刊:Brain Injury
[Informa]
日期:2019-10-29
卷期号:34 (2): 276-280
被引量:6
标识
DOI:10.1080/02699052.2019.1682195
摘要
Objective: The prevalence of chronic growth hormone deficiency (GHD) and its association with other hormonal deficiencies was determined in middle-aged patients post-stroke with and without consideration of body mass index (BMI).Methods: Clinical records were reviewed to determine pituitary function at least 3 months post-stroke. Patients with a history of endocrine anomalies were excluded. GHD was determined by utilizing standard peak GH cutoffs following the glucagon stimulation test. A secondary analysis was conducted with stricter BMI-adjusted cutoffs. The accuracy of IGF-1 in predicting GHD was also examined.Results: GHD was diagnosed in 54% of patients (≥5.0 μg/L), with 32% falling into the severe (≤3 μg/L) category. Patients with GHD had lower levels of FSH, T3, LH, and SHBG. Analyzes of BMI-adjusted GH levels, revealed that 14% of patients were GHD. These patients had higher prolactin. IGF-1 values were not predictive of GHD. Latency to be admitted to post-acute rehabilitation was greater in patients with GHD.Conclusions: Evidence suggests patients with stroke may be at risk for developing GHD. GHD was associated with decreased levels of other hormones. Co-morbidities for stroke and neuroendocrine dysfunction overlap and may have implications for recovery following stroke.
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