Mechanism of nerve injury caused by fluorosis: a review of recent studies

Excessive exposure to fluoride in the environment leads to a variety of health hazards, especially in the nervous system damage. Great number of experimental and clinical data have confirmed that excessive intake of fluoride can cause neurotoxicity, and produce a series of symptoms of central nervous system dysfunction. This review summarizes the mechanisms of neurotoxicity induced by fluorosis in recent years, including oxidative stress, neurotransmitters and receptors, central nervous system signaling molecules, neuronal energy metabolism, and glycosylation end products. This paper analyzes the effects of fluorine exposure on nervous system, thus providing a reliable basis for further prevention and treatment of fluorosis. Key words: Fluorosis; Nervous system; Neurotoxicity; Mechanism research