Clinical analysis of methods of smoking cessation in mild-severe nicotine dependance patients

Objective To analyse the effect of the abstinence from cigarettes with sustained-release bupropion combining with nicotine replacement therapy(NRT)or alone.Methods A retrospective analysis WaS conducted on 112 men and women smoking an average of 24 cigarettes per day and exhibiting a fagerstrom tolerance questionnaire score of 6.0,divided into three groups,two groups were given by only NRT or bupropioragrafin,another group was given by sustained-release bupropion combining with NRT.Results Sixty-two cases were given by NRT alone,11 cases were given by bupropion alone and 39 cases were given by sustained-release bupropion combining with NRT.Three months abstinence of the group given by sustained-release bupropion combining with NRT(58.0%)was higher than that of the group given by NRT or bupropion alone(34.7%,34.2%,all P＜0.05),six months'abstinence was respectively 43.3%,28.5%,25.2%.Withdrawal scores and body nlass increased was lower in the group given by sustainedrelease bupropion combining with NRT than those of the group given by NRT or bupropion alone(P＜0.05).Conclusions Sustained-release bupropion combining with NRT for aiding smoking reduction appears tO be safer and more effective than NRT alone,specially in the patients with chronic disease and female and depression.The analysis and intervention of psychological and behavior show more importance. Key words: Sustained-release bupropion; Nicotine replacement therapy; Relapse situation