拟除虫菊酯
生殖毒性
生物
生殖系统
内分泌干扰物
雌激素受体
内分泌系统
男性生殖系统
毒理
药理学
毒性
杀虫剂
内分泌学
内科学
激素
医学
精子
生态学
遗传学
癌症
乳腺癌
作者
Qi Wang,Jun-Yu Shen,Rui Zhang,Jia-Wei Hong,Zheng Li,Ding Zhang,Heng-Xue Wang,Jinpeng Zhang,Meirong Zhang,Li‐Chun Xu
出处
期刊:Toxicology
[Elsevier]
日期:2020-05-01
卷期号:438: 152460-152460
被引量:36
标识
DOI:10.1016/j.tox.2020.152460
摘要
Synthetic pyrethroids are used as insecticides in agriculture and a variety of household applications worldwide. Pyrethroids are widely distributed in all environmental compartments and the general populations are exposed to pyrethroids through various routes. Pyrethroids have been identified as endocrine-disrupting chemicals (EDCs) which are responsible for the male reproductive impairments. The data confirm pyrethroids cause male reproductive damages. The insecticides exert the toxic effects on male reproductive system through various complex mechanisms including antagonizing androgen receptor (AR), inhibiting steroid synthesis, affecting the hypothalamic-pituitary-gonadal (HPG) axis, acting as estrogen receptor (ER) modulators and inducing oxidative stress. The mechanisms of male reproductive toxicity of pyrethroids involve multiple targets and pathways. The review will provide further insight into pyrethroid-induced male reproductive toxicity and mechanisms, which is crucial to preserve male reproductive health.
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