Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles Amicable for Automation

A three-component 3+2 cycloaddition reaction followed by Suzuki coupling reaction was carried out to synthesize a library of compounds using automation (parallel synthesizer). Scaffolds that are unexplored in literature were used for the synthesis of library. The iodo-triazoles formed by 3+2 cycloaddition reaction were coupled with boronic acids to get tri-substituted triazoles. Keywords: Alkynes, azides, Suzuki reaction, Triazoles, [3+2]-cycloaddition.