Microwave-Assisted Fluorous Multicomponent Reactions – A Combinatorial Chemistry Approach for Green Organic Synthesis

The development of combinatorial chemistry has significantly improved the efficiency of compound library synthesis for highthroughput screening. This technology could also be used to address the green chemistry concerns in organic synthesis. The combination of microwave reactions, multicomponent reactions, and fluorous separations to synthesize organic compounds described in this paper have demonstrated the advantages of energy efficiency, atom economy, easy purification, and reduced amount of waste solvents. Keywords: Fluorous synthesis, microwave reactions, multicomponent reactions, combinatorial chemistry, green chemistry, homogeneous catalysis, chromatography, organic synthesis, compound library synthesis