材料科学
拉曼散射
纳米压印光刻
平版印刷术
纳米技术
生物传感器
制作
软光刻
分析物
基质(水族馆)
检出限
拉曼光谱
光电子学
光学
化学
地质学
物理
病理
物理化学
海洋学
医学
替代医学
色谱法
作者
Maximilien Cottat,Nathalie Lidgi‐Guigui,Frédéric Hamouda,B. Bartenlian,Divya Venkataraman,Robert S. Marks,Terry W. J. Steele,Marc Lamy de la Chapelle
出处
期刊:Journal of Optics
[IOP Publishing]
日期:2015-10-23
卷期号:17 (11): 114019-114019
被引量:15
标识
DOI:10.1088/2040-8978/17/11/114019
摘要
The surface-enhanced Raman scattering (SERS) technique was shown to be an effective molecular analytical tool due to its high sensitivity. Here, we propose to exploit soft UV assisted nanoimprint lithography (UV-NIL) for the development of a reproducible and highly-sensitive SERS biosensor. Soft lithography is known to be advantageous for biological applications since it is compatible with insulating supports and large-area samples. In the present investigations, soft UV-NIL is used for the fabrication of large-sized arrays of gold nanocylinders on glass which were shown to be highly sensitive and highly specific sensing surfaces, with a limit of detection measured down to 1 nM. Employing the UV-NIL SERS substrate enable working ranges of nanomolar to micromolar concentrations in regards to our model paclitaxel analyte.
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