生物膜
细菌
大肠杆菌
金黄色葡萄球菌
铜绿假单胞菌
聚合物
微生物学
材料科学
化学
纳米技术
生物
生物化学
有机化学
遗传学
基因
作者
Andrew L. Hook,Chien‐Yi Chang,Jing Yang,Jeni Luckett,Alan Cockayne,Steve Atkinson,Ying Mei,Roger Bayston,Derek J. Irvine,Robert Langer,Daniel G. Anderson,Paul Williams,Martyn C. Davies,Morgan R. Alexander
摘要
Bacterial attachment and biofilm formation are problematic for medical devices. Hook et al. present a high-throughput method to find materials that resist bacterial attachment and colonization. Bacterial attachment and subsequent biofilm formation pose key challenges to the optimal performance of medical devices. In this study, we determined the attachment of selected bacterial species to hundreds of polymeric materials in a high-throughput microarray format. Using this method, we identified a group of structurally related materials comprising ester and cyclic hydrocarbon moieties that substantially reduced the attachment of pathogenic bacteria (Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli). Coating silicone with these 'hit' materials achieved up to a 30-fold (96.7%) reduction in the surface area covered by bacteria compared with a commercial silver hydrogel coating in vitro, and the same material coatings were effective at reducing bacterial attachment in vivo in a mouse implant infection model. These polymers represent a class of materials that reduce the attachment of bacteria that could not have been predicted to have this property from the current understanding of bacteria-surface interactions.
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