体内
量子点
生物相容性材料
材料科学
分散性
脾脏
临床前影像学
纳米技术
生物医学工程
生物物理学
医学
内科学
生物
生物技术
高分子化学
作者
Ken‐Tye Yong,Indrajit Roy,Hong Ding,Earl J. Bergey,Paras N. Prasad
出处
期刊:Small
[Wiley]
日期:2009-08-26
卷期号:5 (17): 1997-2004
被引量:134
标识
DOI:10.1002/smll.200900547
摘要
Abstract A facile synthesis method to produce monodisperse, biocompatible, lysine crosslinked mercaptoundecanoic acid (MUA) CdSe 0.25 Te 0.75 /CdS near‐infrared (NIR) quantum dots and use them as probes to study their long term in vivo distribution, clearance, and toxicity is presented. Large signal enhancements are demonstrated by these quantum dots, which enables their use as efficient and sensitive probes for live‐animal imaging. An important finding is that mice intravenously injected with ≈10.5 mg kg −1 of NIR QDs survive for more than three months without any apparent adverse effect to their health. Furthermore, it is determined that there is a significant reduction in the number of the QDs in the liver and spleen three months post injection. In addition, histological analysis of heart, kidney, liver, spleen, and lung tissue indicates that there are no acute toxic effects from these lysine cross‐linked MUA NIR QDs. This study suggests that these NIR QDs can be potentially used for long‐term targeted imaging and therapy studies in vivo.
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