Effects of Foeniculum Fructus(FL) and Mixture Water Extracts on Activities of Key Enzymes on Lipid Metabolism

We investigated the effects of feeding diet containing Foeniculum Fructus (FL) water extract and the other herbs mixed water extracts(mixture) on activities of key enzymes such as lipoprotein lipase(LPL), acyl‐CoA synthetase (ACS) and carnitine acetyltransferase(CAT) activities involved in lipid metabolism in high fat diet‐induced obese mice. C57BL/6J mice were fed with HF diet for 11 weeks. In the last 6 weeks, the HF diet was supplemented with 0 (HFD) or FL, mixture(5g/kg, HFD + PL, mixture). The HF‐free diet group was fed normal chow for 11 weeks. LPL and ACS were extracted from the epididymal adipose tissue and liver of C57BL/6J mice after 11 weeks. When 1000 ppm of FL water extract and mixture tested, they decreased LPL activity of obese mice by 12% and 14.8%, respectively. The ACS activity of normal mouse was higher in 1000ppm mixture(152.9%) treatment compared to the control(100%) and the 1000ppm FL(842%) water extract treatment increased the ACS activity of obese mice, compared to the activity in the control(100%). FL(131.2%) and mixture(103.5%) water extract treatment were increased CAT activity compared to the control (100%). Thus, the FL water extract and mixture may have beneficial effects due to activities of enzymes involved in lipid metabolism in obese humans. (This research was supported by the Ministry of Knowledge Economy through the fostering project of the Human Resource Training Project for Regional Innovation.)