生物正交化学
自愈水凝胶
明胶
四嗪
点击化学
降冰片烯
体内
高分子科学
细胞包封
聚合物
高分子化学
生物物理学
化学
聚合
有机化学
生物技术
生物
作者
Sandeep T. Koshy,Rajiv M. Desai,P. Joly,Jianyu Li,Rishi Kesh Bagrodia,Sarah A. Lewin,Neel Joshi,David J. Mooney
标识
DOI:10.1002/adhm.201500757
摘要
Injectable gelatin hydrogels formed with bioorthogonal click chemistry (ClickGel) are cell-responsive ECM mimics for in vitro and in vivo biomaterials applications. Gelatin polymers with pendant norbornene (GelN) or tetrazine (GelT) groups can quickly and spontaneously crosslink upon mixing, allowing for high viability of encapsulated cells, establishment of 3D elongated cell morphologies, and biodegradation when injected in vivo.
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