Synthesis and characterization of novel azole heterocycles based on 2,5-disubstituted thiadiazole

The development of simple synthetic routes to widely used organic compounds using readily available reagents is one of the main objectives of organic synthesis. Nitrogen heterocycles are of a special interest because they constitute an important class of natural and nonnatural products, many of which exhibit useful biological activities. One-pot efficient synthesis of heterocyclic derivatives may permit the development of novel therapies for the treatment of epilepsy, pain and other neurodegenerative disorders. Pyrazoles have attracted much attention recently as their synthesis is more accessible and their diverse properties are appreciated. One of the most important pyrazole activities are the effective antirheumatoidal (SC-58635 Celecoxib) and antiviral agents (Pyrazomycin), hormone oxytocin agonists (WAY-VNA-932), and selective Human C1s inhibitors. 1,2,4-Triazole and its derivatives are found to be associated with various biological activities. For example, Fluconazole is used as an antimicrobial drug, while Vorozole, Letrozole, and Anastrozole are nonsteroidal used for treatment of cancer and Loreclezole is used as an anticonvulsant. Also, the synthesis of triazoles fused to another heterocyclic ring, especially those in which triazoles fused to thiadiazoles, has attracted particular attention due to their diverse applications. Some Schiff bases bearing aryl groups or heterocyclic residues possess excellent biological activities, which has attracted many researchers’ attention in recent year. They have been reported to be used as analgesic, anthelmintic, antitubercular, plant growth regulator, antiviral, antifungal, and anticancer.