免疫疗法
医学
放射治疗
免疫系统
逃避(道德)
肿瘤科
内科学
免疫学
作者
Maureen Aliru,Jonathan E. Schoenhals,Bhanu Prasad Venkatesulu,Clark Anderson,Hampartsoum B. Barsoumian,Ahmed Younes,Lakshmi Mahadevan,Melinda Soeung,Kathryn E. Aziz,James Welsh,Sunil Krishnan
出处
期刊:Immunotherapy
[Future Medicine]
日期:2018-03-01
卷期号:10 (4): 299-316
被引量:49
标识
DOI:10.2217/imt-2017-0082
摘要
Radiotherapy is a component of the standard of care for many patients with locally advanced nonmetastatic tumors and increasingly those with oligometastatic tumors. Despite encouraging advances in local control and progression-free and overall survival outcomes, continued manifestation of tumor progression or recurrence leaves room for improvement in therapeutic efficacy. Novel combinations of radiation with immunotherapy have shown promise in improving outcomes and reducing recurrences by overcoming tumor immune tolerance and evasion mechanisms via boosting the immune system's ability to recognize and eradicate tumor cells. In this review, we discuss preclinical and early clinical evidence that radiotherapy and immunotherapy can improve treatment outcomes for locally advanced and metastatic tumors, elucidate underlying molecular mechanisms and address strategies to optimize timing and sequencing of combination therapy for maximal synergy.
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