胃肠病学
阿莫西林
随机对照试验
质子抑制剂泵
外科
甲硝唑
作者
Periklis Apostolopoulos,Ioannis Koumoutsos,Konstantinos A. Ekmektzoglou,Panagiotis Dogantzis,Erasmia Vlachou,Chrisostomos Kalantzis,Panagiotis Tsibouris,Georgios Alexandrakis
标识
DOI:10.3109/00365521.2015.1079646
摘要
AbstractObjective: The objective of this study is to compare, in Greece, a region with >20% local resistance to clarithromycin, the efficacy rates of the concomitant versus the sequential H. pylori eradication therapy. Materials and methods: Our prospective randomized study included 364 patients with newly diagnosed H. pylori infection, randomized to receive a 10-day concomitant or 10-day sequential therapy. Treatment outcome was assessed by C13-urea breath test at least 4 weeks after therapy. Intention to treat (ITT) and per protocol (PP) analysis of the eradication rates were performed. Secondary end points included patient compliance and safety. Results: The concomitant therapy group achieved statistically significant higher eradication rates when compared with the sequential treatment group, both in the ITT and in the PP analysis (84.6% versus 70.9%, p = 0.002, and 90.6% versus 78.1%, p = 0.001, respectively), after adjusting for age, gender, smoking status, and the presence or not of ulcer and/or non...
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