Synthesis of Sterically Hindered 1,3‐Diketones

Abstract An efficient and practical method for the synthesis of sterically hindered aliphatic/aromatic 1,3‐diketones via coupling of ketones with esters using potassium tert‐butoxide is described. The protocol requires milder operating conditions, and the products are obained in good to excellent yields. Keywords: claisen condensation1,3‐diketoneesterpotassium tert‐butoxide Acknowledgments Financial assistance from Department of Atomic Energy/Board of Research in Nuclear Sciences (DAE/BRNS) is acknowledged.