合成子
化学
表面改性
催化作用
过氧化物
组合化学
卤化
有机化学
药物化学
物理化学
作者
Laimujam Sidartha Singh,Arup K. Kabi,Ragini Sengupta,Anupam Roy,Abhishek Sahoo,Indranil Saha,Chandi C. Malakar
出处
期刊:Asian Journal of Chemistry
[Asian Journal of Chemistry]
日期:2022-01-01
卷期号:34 (7): 1841-1847
标识
DOI:10.14233/ajchem.2022.23769
摘要
This work describes an easy way to perform approach for the transformation of arylmethyl ketones to α-ketoamides using secondary amines as starting materials in the presence of iodine as a catalyst in water under peroxide free reaction conditions. The established amidation reaction proceeds via α-C(sp3)-H functionalization and C-N bond formation approaches in water at ambient temperature. On the other hand, a novel and straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via nickel-catalyzed cyclization of amidines with DMSO as one-carbon synthon has been developed. The developed strategy proceeds via C-N bond formation.
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