Structural characteristics and immunostimulatory activity of sea cucumber tendon polysaccharides in cyclophosphamide-induced Balb/c mice

and reduce the relative abundance of Lachnospiraceae_NK4A136_group and Rikenellaceae_RC9_gut_group. These results demonstrate that SCPII possesses potential immunoregulatory activities in cyclophosphamide-induced mice by regulating intestinal microbiota diversity and improving immune organs, enhancing the proliferation ability of macrophages and splenocyte proliferation, and enhancing intestinal physical barrier function, which might provide important evidence for the development and utilization of the viscera of sea cucumber.