细胞凋亡
转录组
程序性细胞死亡
诱导剂
细胞生物学
生物
细胞
细胞培养
乙醇
癌症研究
生物化学
基因表达
基因
遗传学
作者
Ho Man Tang,C. Conover Talbot,Ming Chiu Fung,Ho Lam Tang
标识
DOI:10.1038/s41597-022-01470-8
摘要
Abstract Anastasis is a cell recovery mechanism that rescues dying cells from the brink of death. Reversal of apoptosis is the first example of anastasis. Here, we describe a comprehensive dataset containing time-course mRNA expression profiles for reversal of ethanol-induced apoptosis in mouse primary liver cells in νitro . This transcriptome dataset includes the conditions of the untreated cells, cells undergoing apoptosis triggered by incubating with cell death inducer of 4.5% ethanol for 5 hours, and apoptosis reversal of ethanol-induced cells at the early (3 rd hour), middle (6 th hour), and late (24 th , 48 th hour) stages after being washed with and incubated in fresh cell culture medium. By comparing this dataset with the transcriptomic profiles of other anastasis models generated with different combinations of cell types and cell death inducers, investigators can identify the key regulators governing reversal of apoptosis and other reversible cell death processes. Therefore, reusing or reanalysing this dataset will facilitate the future studies on the physiological, pathological, and therapeutic implications of anastasis.
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