生物
表位
病毒学
人类白细胞抗原
细胞毒性T细胞
CD8型
冠状病毒
免疫学
免疫系统
免疫
T细胞
T细胞受体
抗原
遗传学
2019年冠状病毒病(COVID-19)
疾病
传染病(医学专业)
体外
病理
医学
作者
Garry Dolton,Cristina Rius,Md. Faruk Hasan,Aaron Wall,Barbara Szomolay,Enas M. Behiry,Thomas Whalley,Joel Southgate,Anna Fuller,Théo Morin,Katie Topley,Li Rong Tan,Philip Goulder,Owen B. Spiller,P.J. Rizkallah,Lucy C. Jones,Thomas R. Connor,Andrew K. Sewell
出处
期刊:Cell
[Elsevier]
日期:2022-08-01
卷期号:185 (16): 2936-2951.e19
被引量:49
标识
DOI:10.1016/j.cell.2022.07.002
摘要
We studied the prevalent cytotoxic CD8 T cell response mounted against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike glycoprotein269-277 epitope (sequence YLQPRTFLL) via the most frequent human leukocyte antigen (HLA) class I worldwide, HLA A∗02. The Spike P272L mutation that has arisen in at least 112 different SARS-CoV-2 lineages to date, including in lineages classified as "variants of concern," was not recognized by the large CD8 T cell response seen across cohorts of HLA A∗02+ convalescent patients and individuals vaccinated against SARS-CoV-2, despite these responses comprising of over 175 different individual T cell receptors. Viral escape at prevalent T cell epitopes restricted by high frequency HLAs may be particularly problematic when vaccine immunity is focused on a single protein such as SARS-CoV-2 Spike, providing a strong argument for inclusion of multiple viral proteins in next generation vaccines and highlighting the need for monitoring T cell escape in new SARS-CoV-2 variants.
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