Dermal nanomedicine: Uncovering the ability of nucleic acid to alleviate autoimmune and other related skin disorders

Various skin problems are affected significantly by a combination of factors that include genetics, environmental factors, particular infections, and hitherto unexplained variables. The structure and function of key cellular networks may be altered by a single mutation, leading to significant phenotypic changes and the development of abnormal skin disorders in affected individuals. In recent years, there has been a great deal of discussion about the huge medicinal potential of nucleic acids. Although nucleic acids may be delivered to the desired location, there are a number of difficulties that must be solved before they can be used in clinical trials. Providing a comprehensive overview of numerous facts that highlight a range of skin-related autoimmune illnesses, as well as the use of dermal nanomedicine as a powerful tool for personalized therapy in the context of nuclear acid delivery, is our primary purpose in this paper. The most recent emerging trends and up-to-date metadata on various perspectives of dermal nanomedicines in different autoimmune diseases and related skin conditions as potential candidates for nucleic acid delivery have been gathered from a variety of databases that have been searched for potentially existing research to obtain the most recent emerging trends and up-to-date metadata. Existing research indicates that nanomedicines integrating nucleic acid, including liposomes, dendrimers, polymeric micelles, and other forms of nucleic acid delivery, have significant promise in the pharmaceutical industry. The current investigation focuses on the delivery of nucleic acid medications through the dermal route, as well as the therapeutic applications of these agents. Furthermore, the current state of nanomedicines has been discussed, as well as their potential and use.