Research Progress in Radical Cascade Reaction Using Nitrogen Heterocycle in Indoles as Radical Acceptors

Indole skeleton has been widely utilized in the synthesis and late-stage modification of biologically active compounds, especially in the fields of medicines and pesticides.In recent years, constructing spiro compounds by asymmetric dearomatization of indoles has become extremely promising.Meanwhile, the radical tandem reaction of unsaturated bonds has been a significant branch of organic chemistry, and this methodology has become a crucial approach to modify the indole skeleton.Therefore, the recent progress in the field of radical cascade reaction of unsaturated hydrocarbon using nitrogen heterocycle in indoles as radical acceptors is summarized.Besides, the reaction design, mechanism and prospects of this field are also discussed.