阿米洛利
化学
甲磺酸
药理学
胺气处理
可乐定
铜
医学
钠
麻醉
有机化学
作者
Rodolfo Federico,Riccardo Angelini,Luca Ercolini,Giorgio Venturini,Andrea Mattevi,Paolo Ascenzi
标识
DOI:10.1006/bbrc.1997.7630
摘要
Competitive inhibition of swine kidney copper amine oxidase by diuretic, antihypertensive, and anticoagulant drugs, amiloride, clonidine, and gabexate mesylate, respectively, is reported. The affinity of these compounds for swine kidney copper amine oxidase is similar to that observed for inhibitor binding to nitric oxide synthase and trypsin-like serine proteinases. This finding suggests that amiloride, clonidine, and gabexate mesylate should be administrated under careful control, since enzyme cross-inhibition may occur also in vivo.
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