血脑屏障
神经科学
药物输送
药物输送到大脑
中枢神经系统
药品
神经血管束
医学
药物开发
计算机科学
药理学
心理学
纳米技术
病理
材料科学
作者
Joana Bicker,Gilberto Alves,Ana Fortuna
标识
DOI:10.1016/j.ejpb.2014.03.012
摘要
During the research and development of new drugs directed at the central nervous system, there is a considerable attrition rate caused by their hampered access to the brain by the blood–brain barrier. Throughout the years, several in vitro models have been developed in an attempt to mimic critical functionalities of the blood–brain barrier and reliably predict the permeability of drug candidates. However, the current challenge lies in developing a model that retains fundamental blood–brain barrier characteristics and simultaneously remains compatible with the high throughput demands of pharmaceutical industries. This review firstly describes the roles of all elements of the neurovascular unit and their influence on drug brain penetration. In vitro models, including non-cell based and cell-based models, and in vivo models are herein presented, with a particular emphasis on their methodological aspects. Lastly, their contribution to the improvement of brain drug delivery strategies and drug transport across the blood–brain barrier is also discussed.
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