生物
细胞凋亡
癌基因
小分子
原癌基因蛋白质c-myc
癌症研究
转录因子
细胞生物学
N-Myc公司
神经母细胞瘤
细胞培养
基因
细胞周期
遗传学
神经节细胞瘤
作者
Hao Yuan Mo,Marina Vita,Marianne Crespin,Marie Arsenian Henriksson
出处
期刊:Cell Cycle
[Informa]
日期:2006-09-22
卷期号:5 (19): 2191-2194
被引量:33
摘要
The Myc oncogene is deregulated in a wide variety of human tumors hence the Myc pathway is an attractive target for tailored cancer treatment. We have recently identified two small molecules, MYRAs (Myc-pathway response agents), that induce apoptosis in a Myc-dependent manner and inhibit Myc-driven transformation. Here, we show that these compounds in addition have prominent effects in MYCN overexpressing neuroblastoma cells. A third compound, NSC308848, also induced apoptosis in Myc-overexpressing cells and inhibited Myc-induced cellular transformation. However, in contrast to the MYRAs, NSC308848 treatment resulted in decreased Myc protein levels and gave rise to inhibitory effects also on other transcription factors than Myc. Taken together, our findings suggest that these three small molecules can elicit a similar biological response by interfering with the Myc pathway at different levels.
科研通智能强力驱动
Strongly Powered by AbleSci AI