软骨发生
再生(生物学)
间充质干细胞
软骨
干细胞
透明软骨
干细胞移植修复关节软骨
软骨细胞
细胞生物学
组织工程
关节软骨修复
医学
再生医学
病理
生物
解剖
关节软骨
细胞分化
成体干细胞
生物医学工程
骨关节炎
替代医学
基因
生物化学
作者
Brendan Jones,Ming Pei
出处
期刊:Tissue Engineering Part B-reviews
[Mary Ann Liebert]
日期:2012-08-01
卷期号:18 (4): 301-311
被引量:150
标识
DOI:10.1089/ten.teb.2012.0002
摘要
Articular cartilage is difficult to heal once injury or disease occurs. Autologous chondrocyte transplantation is a biological treatment with good prognosis, but donor site morbidity and limited cell source are disadvantages. Currently, mesenchymal stem cells (MSCs) are a promising approach for cartilage regeneration. Despite there being various sources, the best candidate for cartilage regeneration is the one with the greatest chondrogenic potential and the least hypertrophic differentiation. These properties are able to insure that the regenerated tissue is hyaline cartilage of high quality. This review article will summarize relevant literature to justify synovium-derived stem cells (SDSCs) as a tissue-specific stem cell for chondrogenesis by comparing synovium and cartilage with respect to anatomical location and functional structure, comparing the growth characterization and chondrogenic capacity of SDSCs and MSCs, evaluating the application of SDSCs in regenerative medicine and diseases, and discussing potential future directions.
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