医学
支气管肺泡灌洗
特发性肺纤维化
肺
结节病
慢性阻塞性肺病
胃肠病学
病理
肺炎
特发性间质性肺炎
肺癌
间质性肺病
隐源性机化性肺炎
内科学
哮喘
外源性过敏性肺泡炎
呼吸道疾病
免疫学
作者
Qing Ye,Masaki Fujita,Hiroshi Okumura,Ichiro Inoshima,Takashige Maeyama,Kazuyoshi Kuwano,Yasuhiro Horiuchi,Nobuyuki Hara,Yoichi Nakanishi
出处
期刊:Respiration
[S. Karger AG]
日期:2004-01-01
卷期号:71 (5): 505-510
被引量:36
摘要
<i>Background:</i> Although Clara cell secretory protein (CC-10) has been ascribed an anti-inflammatory role in lung diseases, its precise role remains unclear. <i>Objective:</i> To further our understanding of the role of CC-10 in inflammatory lung diseases, CC-10 protein levels were measured. <i>Methods:</i> Sera or bronchoalveolar lavage (BAL) fluids were collected from patients with different inflammatory lung diseases including bronchial asthma, chronic obstructive lung disease (COPD), sarcoidosis, idiopathic interstitial pneumonia (IIP), chronic eosinophilic pneumonia (CEP), pneumonia and lung cancer. Serum CC-10 concentrations were measured by enzyme-linked immunosorbent assay using urinary protein-1 antibody. Then, the relationships between CC-10 concentrations and lung diseases were investigated. Immunohistochemistry was performed using lung biopsy samples. <i>Results:</i> Increased serum CC-10 levels were recognized in IIP patients, while CC-10 levels were decreased in bronchial asthma patients and CEP patients. Immunohistochemistry revealed an aberrant expression in areas of fibrosis in IIP patients. Serum CC-10 concentrations were not associated with severity among IIP, COPD, and sarcoidosis. In contrast, serum CC-10 concentrations were correlated with FEV<sub>1</sub>/FVC in bronchial asthma patients. <i>Conclusions:</i> Although the number of patients was quite limited, these data provide new insights into the role of CC-10 in lung diseases, and the possibility that the CC-10 concentration in serum could be a new marker indicating the severity of bronchial asthma.
科研通智能强力驱动
Strongly Powered by AbleSci AI