SURVIVAL OF ENGRAFTED TISSUES

A great deal has been written on the subject of survival of engrafted tissues, and, as might be expected, many conflicting results have been reported.It is not our present purpose to review extensively the literature, ~ but rather to present some additional observations.Reference will be made to the work of other investigators in so far as may seem necessary in acknowledging priority, or in discussing results.M e t h o d s .--W e have employed two methods: (a) simple transplantation, that is, transplanting without anastomosis of blood vessels; and (b) transplantation with anastomosis of blood vessels.Blood vessel grafts for the purpose of restoring the continuity of blood vessels occupy a peculiar position and will be dealt with in the third paper of this series.A. Simple Transplanting or E n g r a f t i n g .--B y this method tissues are removed and replaced, or are placed in a new situation in the animal from which they are removed, under the skin, into the peritoneal or other cavity, into organs, such as the liver or spleen, into muscle, the cavity of bones, etc.Such an operation is termed an auto-or homo-transplantation or graft.If the tissue be placed into 1Received for publication January 17, IgIO.The second paper of this series entitled "II.(A) Thyroid (including parathyroid) and (B) Kidney (including adrenal) " appeared in The Journal of the American Medical Association, 191o, liv, 83I.