光遗传学
长时程增强
神经科学
恐惧条件反射
突触可塑性
记忆巩固
扁桃形结构
条件作用
心理学
海马体
计算机科学
生物
数学
生物化学
统计
受体
作者
Sadegh Nabavi,Rocky Fox,Christophe D. Proulx,John Y. Lin,Roger Y. Tsien,Roberto Malinow
出处
期刊:Nature
[Springer Nature]
日期:2014-06-01
卷期号:511 (7509): 348-352
被引量:779
摘要
It has been proposed that memories are encoded by modification of synaptic strengths through cellular mechanisms such as long-term potentiation (LTP) and long-term depression (LTD). However, the causal link between these synaptic processes and memory has been difficult to demonstrate. Here we show that fear conditioning, a type of associative memory, can be inactivated and reactivated by LTD and LTP, respectively. We began by conditioning an animal to associate a foot shock with optogenetic stimulation of auditory inputs targeting the amygdala, a brain region known to be essential for fear conditioning. Subsequent optogenetic delivery of LTD conditioning to the auditory input inactivates memory of the shock. Then subsequent optogenetic delivery of LTP conditioning to the auditory input reactivates memory of the shock. Thus, we have engineered inactivation and reactivation of a memory using LTD and LTP, supporting a causal link between these synaptic processes and memory.
科研通智能强力驱动
Strongly Powered by AbleSci AI