[Studies on stability of chlorogenic acid in extract of Flos lonicerae].

OBJECTIVE: To investigate the stability of chlorogenic acid in extract of flos lonicerae in different conditions. METHOD: The stability of chlorogenic acid in extract of flos lonicerae in phosptat buffe with different pH values, methanol, ethanol and different base solutions(Ca(OH)2 and NaOH) was investigated by the classical isothermal method. RESULT: The experiments showed the chlorogenic acid in extract of flos lonicerae was more stable in acidic water than in basic water. It was stable in these organic solutions and base solution[Ca(OH)2]. CONCLUSION: In different conditions, the stability of chlorogenic acid in extract of flos lonicerae was different. It provided a reference to the extraction and analysis of chlorogenic acid and production of chlorogenic acid preparation.