Effect of jinlong capsule combined with hepatectomy on HCC intrahepatic metastasis

OBJECTIVE:To investigate the therapeutic effectiveness of jinlong capsule on intrahepatic metastasis and cellular immunity after hepatectomy in hepatocellular carcinoma(HCC) in human.METHODS:A total of 122 cases with resectable hepatocellular carcinoma were collected and divided into two groups randomly:a jinlong capsule combined with hepatectomy group(treatment group) and control group.The serous values of T lymphocyte phenotypes,NK cells,AFP and MMP-9 were measured respectively;B ultrasonic and CT were used to detected for intrahepatic dissemination and recurrence of HCC after the hepatectomy,with B ultrasonic test every month and CT test every three months,respectively.The therapeutic effectiveness was evaluated by UICC standard,the quality of life was evaluated by Karnofsky method,and the survival of patients was evaluated by Kaplan-Meier.RESULTS:After the treatment,the serous levels of CD4+/CD8+ and NK cells in the control group were much lower than those in the treatment group,P0.05.There was no difference of the serous levels of AFP between the two groups after the operation,but MMP-9 levels in the treatment group were much lower than those in the control group,P0.05.The recurrence rate of intrahepatic dissemination in the treatment group(37.7%,23/61) was much lower than that in the control group(60.6%,37/61),P0.05.The survival time(mean days or median days) in the treatment group were longer than those in the control group(P=0.001),and the effective rate and quality of life of the treatment group were significantly better than those of the control group,P0.05.CONCLUSION:Jinlong capsule combined with hepatectomy for HCC patients has no effect on cellular immunity,can decrease the serous level of MMP-9,inhibit intrahepatic dissemination,and improve the effectiv rate,survival time and the quality of life of patients with HCC.