Study on Formulation of Breviscapine in Situ Nasal Thermoreversible Gel

Objective:To prepare a Breviscapine in situ nasal thermoreversible gel.Methods:With Poloxamer 407 and Poloxamer 188 as gel base,the gelation temperature was investigated by stirrer.Results:19% Poloxamer 407 and 4% Poloxamer 188 were established as the best compositions of the gel base,and its gelation temperature was 32.9 ℃,which was suitable for drug delivery system of nasal.Conclusion:The temperature of Brethermosensitive gel was close to the temperature of asal cavity,so it is suitable for drug delivery system of nasal cavity.