半胺
化学
烷基化
催化作用
醛
基础(拓扑)
胺气处理
有机化学
小学(天文学)
组合化学
天文
数学
物理
数学分析
作者
Qiang‐Qiang Li,Zu‐Feng Xiao,Chuan‐Zhi Yao,Hang Zheng,Yan‐Biao Kang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2015-10-16
卷期号:17 (21): 5328-5331
被引量:57
标识
DOI:10.1021/acs.orglett.5b02685
摘要
A base-catalyzed/promoted transition-metal-free direct alkylation of amines with alcohols has been developed, giving the desired amines in generally high yields from either aromatic or aliphatic alcohols. On the basis of the (1)H NMR and in situ IR (React-IR) monitoring experiments, isotope-labeling experiments, as well as control experiments, a novel "hemiaminal" model is proposed to understand the mechanism, which explains the formation of the "extra" aldehyde in the reaction.
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