The Effect of Polysaccharide from Mycelia and Spores of Agaricus Blazei Mnrill on IL-2, NK of Gastric Cancer Rat and the Antitumor Mechanism

Objective To explore the effect of polysaccharide from mycelia and spores of Agaricus blazei Murill on IL-2, NK of gastric cancer rat and the antitumor mechanism. Methods The Wistar rats were randomly divided into five groups. Except for normal control group, the other four groups were injected Arac and radiated with 60Co, then transplanted with BGC-823 gastric cancer cells to form gastric cancer rat models. Three groups of which were treated separately by Lentinus edodes polysaccharides (LP), polysaccharide from mycelia and spores of Agaricus blazei Murill (MP) high dose and low dose. The normal control group and the model control group were gived NS. Ten days later, we observed the activity or content of IL-2, NK and the growth of tumor in each experimental group. Results The content of IL-2, and the activity of NK decreased obviously in tumor-bearing animals (P0.01). After treating, the IL-2 and the activity of NK increased obviously than that of model control group (P0.01 or P0.05). The effect of high-dose MP group is more obvious than LP group (P0.05). Conclnsion MP has positive immune regulatory effect on IL-2, NK of gastric cancer rats and tumor inhibiting effect.