Highly Regulated Supramolecular Assembly of 2-O-Methylated α-Cyclodextrin to Construct Vertically Oriented Microrods on Graphite

Precisely controlling self-assembled molecules to fabricate highly ordered nano/microstructures is a challenging task. Here, a simple precipitation technique with common solvents forms supramolecular microstructures with highly regulated molecular arrangements from a methylated derivative of α-cyclodextrin at the 2-O position (2-Me-α-CD). The formation of a head-to-tail channel assembly of 2-Me-α-CD through host-guest complexation with a solvent molecule such as benzene or cyclohexane yields well-defined hexagonal microrods. Specifically, the self-assembly of 2-Me-α-CD forms vertically aligned hexagonal microrods on a highly ordered pyrolytic graphite (HOPG) surface via epitaxial growth. This work should provide insight into the design of supramolecular building blocks for controlled self-assembly.