材料科学
光热治疗
纳米探针
壳聚糖
生物相容性
聚合
原位聚合
化学工程
复合数
聚合物
纳米复合材料
光热效应
纳米技术
纳米颗粒
复合材料
冶金
工程类
作者
Jian Meng,Qian Wang,Shilei Ren,Lei Wang,Ruiping Zhang
标识
DOI:10.1016/j.matlet.2021.131400
摘要
Photothermal therapy (PTT) is a new treatment, and photoacoustic (PA) imaging-guided PTT has aroused extensive attention recently. Poly-2-phenyl-benzobisthiazole (PB) is a new type of conjugated polymer with good biocompatibility and excellent photothermal properties similar to single-walled CNT. However, the poor hydrophilicity of PB limits its application in biomaterials. In this work, chitosan-Cu(II) network structure was first constructed, and then the Cu(II) in-situ initiated the polymerization of aminobenzenedithiophenol and terephthalonitrile to obtain chitosan/PB composite. The excellent hydrophilicity of chitosan-based nanoparticle has successfully improved the water solubility of the obtained nanoprobe PB/CS. Additionally, PB/CS has an excellent PA signal. Thus, a simple and convenient nanosystem was fabricated and applied for PA imaging-guided PTT.
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