甲酰化
化学
配体(生物化学)
催化作用
部分
磷化氢
羰基化
三丁基膦
组合化学
药物化学
甲基化
胺气处理
有机化学
一氧化碳
受体
基因
生物化学
作者
Wen‐Duo Li,Dongsheng Zhu,Gang Li,Jie Chen,Ji‐Bao Xia
标识
DOI:10.1002/adsc.201900906
摘要
Abstract We herein describe an efficient iron‐catalyzed selective N ‐methylation and N ‐formylation of amines with CO 2 and silane using mono‐phosphine as ligand. With commercially available [CpFe(CO) 2 ] 2 as catalyst, Fe‐catalyzed methylation of amines was achieved with triphenylphosphine as a ligand. Using tributylphosphine as a ligand, Fe‐catalyzed formylation of amines was realized at a lower temperature. The method was successfully applied in the late‐stage methylation and formylation of drug molecules containing amine moiety. magnified image
科研通智能强力驱动
Strongly Powered by AbleSci AI