糖酵解
氧化还原
乳酸脱氢酶
平衡
厌氧糖酵解
线粒体
柠檬酸循环
生物
化学
生物化学
新陈代谢
细胞生物学
酶
有机化学
作者
Evan Quon,Madeleine Hart,Lucas B. Sullivan
标识
DOI:10.1016/j.trecan.2020.02.012
摘要
Lactate dehydrogenase (LDH) accounts for the fermentative component of aerobic glycolysis, a near ubiquitous metabolic alteration in cancer. Recently, Oshima et al. developed a bioavailable LDH inhibitor that decreases tumor growth in mice and functions synergistically with mitochondrial respiration inhibitors. These findings suggest a cooperative mechanism of action that targets redox homeostasis.
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