医学
Blinatumoab公司
药效学
药代动力学
霍奇金淋巴瘤
淋巴瘤
药理学
肿瘤科
内科学
白血病
淋巴细胞白血病
作者
Youssef Hijazi,Matthias Klinger,Andrea Kratzer,Benjamin Wu,Patrick A. Baeuerle,Peter Kufer,Andreas Wolf,Dirk Nagorsen,Min Zhu
出处
期刊:Current Clinical Pharmacology
[Bentham Science]
日期:2018-08-20
卷期号:13 (1): 55-64
被引量:19
标识
DOI:10.2174/1574884713666180518102514
摘要
Background: Blinatumomab is a bispecific T-cell engager (BiTE®) antibody construct targeting CD3ε on T cells and CD19 on B cells. We describe the relationship between pharmacokinetics (PK) of blinatumomab and pharmacodynamic (PD) changes in peripheral lymphocytes, serum cytokines, and tumor size in patients with non-Hodgkin lymphoma (NHL). Methods: In a phase 1 study, 76 patients with relapsed/refractory NHL received blinatumomab by continuous intravenous infusion at various doses (0.5 to 90 µg/m2/day). PD changes were analyzed with respect to dose, blinatumomab concentration at steady state (Css), and cumulative area under the concentration-versus-time curve (AUCcum). Results: B-cell depletion occurred within 48 hours at doses ≥5 µg/m2/day, followed first-order kinetics, and was blinatumomab exposure-dependent. Change in tumor size depended on systemic blinatumomab exposure and treatment duration and could be fitted to an Emax model, which predicted a 50% reduction in tumor size at AUCcum of ≥1,340 h×µg/L and Css of ≥1,830 pg/mL, corresponding to a blinatumomab dose of 47 µg/m2/day for 28 days. The magnitude of transient cytokine elevation, observed within 1-2 days of infusion start, was dose-dependent, with less pronounced elevation at low starting doses. Conclusion: B-lymphocyte depletion following blinatumomab infusion was exposure-dependent. Transient cytokine elevation increased with dose; it was less pronounced at low starting doses. Tumor response was a function of exposure, suggesting utility for the PK/PD relationship in dose selection for future studies, including NHL and other malignant settings. Keywords: Blinatumomab, BiTE®, non-Hodgkin lymphoma, exposure-response, pharmacokinetics, pharmacodynamics.
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