Measurement and Correlation of the Solubility of Mifepristone in Eight Pure and Water + Methanol Mixed Solvents at Temperatures from 273.15 to 318.15 K

The solubility of Mifepristone in eight pure organic solvents, including methanol, ethanol, n-propanol, isopropanol, n-butanol, propanone, ethyl acetate, tetrahydrofuran, and mixed solvents of water + methanol have been experimented at 273.15–318.15 K by using an experimental method of high-performance liquid chromatography. The solubility data in eight pure solvents was correlated by the modified Apelblat equation, Van't Hoff equation, λh equation, NRTL equation, UNIQUAC equation, and Wilson equation. The solubility data in the mixed solvents of water + methanol was correlated by the modified Apelblat equation, Van't Hoff equation, λh equation, NRTL equation, UNIQUAC equation, Jouyban–Van't Hoff equation, and Jouyban–Apelblat equation. The solubility of the Mifepristone in eight pure solvents and mixed solvents increased as the temperature increased. The calculated values by using the modified Apelblat equation, Van't Hoff equation, λh equation, NRTL equation, UNIQUAC equation, Jouyban–Van't Hoff equation and Jouyban–Apelblat equation is consistent with the experimental values. The experimental results and calculated values would be very useful in the purification and the synthesis process of Mifepristone.