地奥司明
明胶
薄脆饼
体内
材料科学
傅里叶变换红外光谱
生物医学工程
肉芽组织
纳米晶
造粒
扫描电子显微镜
粘附
化学工程
化学
纳米技术
医学
复合材料
伤口愈合
外科
生物化学
生物
生物技术
工程类
抗氧化剂
类黄酮
作者
Nouran M. Atia,Heba A. Hazzah,Passent M.E. Gaafar,Ossama Y. Abdallah
标识
DOI:10.1016/j.xphs.2018.12.019
摘要
This work aimed at loading of diosmin nanocrystals into alginate-based wafers for treatment of highly exuding diabetic ulcer in rats using topical route of administration. For this purpose, different formulation variables and preparation techniques to enhance the flexibility and adhesion properties of the prepared sodium alginate (SA) wafers were carried out. The prepared wafers were characterized regarding hydration capacity, bioadhesion, scanning electron microscope, and Fourier-transform infrared spectroscopy. Efficacy of treating diabetic ulcer was studied using diabetic-induced rat model using streptozotocin. Results obtained showed that using SA:gelatin with 1.5%/1.5% w/w gave acceptable wafers with a sustained release of diosmin over 8 h. A complete re-epithelialization, well-organized dermal layers, well-formed granulation tissue, and mature collagen bundles were observed in treated rats. It was concluded that combination of gelatin with SA provided an excellent wafer as a promising medicated wound dressing holding diosmin nanocrystals while maintaining its stability.
科研通智能强力驱动
Strongly Powered by AbleSci AI