DNA甲基化
神经发生的表观遗传调控
表型
乙酰化
表观遗传疗法
表观遗传学
炎症
癌症研究
癌症表观遗传学
功能(生物学)
组蛋白
细胞生物学
生物
免疫学
遗传学
组蛋白甲基转移酶
DNA
基因表达
基因
作者
Peng Sun,Shujing Zhang,Semenov Maksim,Yongfang Yao,Hong‐Min Liu,Juan Du
标识
DOI:10.2174/1568026619666190619143706
摘要
Macrophages are essential for supporting tissue homeostasis, regulating immune response, and promoting tumor progression. Due to its heterogeneity, macrophages have different phenotypes and functions in various tissues and diseases. It is becoming clear that epigenetic modification playing an essential role in determining the biological behavior of cells. In particular, changes of DNA methylation, histone methylation and acetylation regulated by the corresponding epigenetic enzymes, can directly control macrophages differentiation and change their functions under different conditions. In addition, epigenetic enzymes also have become anti-tumor targets, such as HDAC, LSD1, DNMT, and so on. In this review, we presented an overview of the latest progress in the study of macrophages phenotype and function regulated by epigenetic modifications, including DNA methylation and histone modifications, to better understand how epigenetic modification controls macrophages phenotype and function in inflammation-associated diseases, and the application prospect in anti-tumor.
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