炎症
脂多糖
医学
脑水肿
缺氧(环境)
小胶质细胞
全身炎症
血管通透性
血脑屏障
免疫学
内科学
水肿
中枢神经系统
化学
氧气
有机化学
作者
Yanzhao Zhou,Xin Huang,Tong Zhao,Meng Qiao,Xingnan Zhao,Ming Zhao,Ling Xu,Yong-Qi Zhao,Liying Wu,Kuiwu Wu,Ruoli Chen,Ming Fan,Lijing Zhu
标识
DOI:10.1016/j.bbi.2017.04.013
摘要
High altitude cerebral edema (HACE) is a life-threatening illness that develops during the rapid ascent to high altitudes, but its underlying mechanisms remain unclear. Growing evidence has implicated inflammation in the susceptibility to and development of brain edema. In the present study, we investigated the inflammatory response and its roles in HACE in mice following high altitude hypoxic injury. We report that acute hypobaric hypoxia induced a slight inflammatory response or brain edema within 24h in mice. However, the lipopolysaccharide (LPS)-induced systemic inflammatory response rapidly aggravated brain edema upon acute hypobaric hypoxia exposure by disrupting blood-brain barrier integrity and activating microglia, increasing water permeability via the accumulation of aquaporin-4 (AQP4), and eventually leading to impaired cognitive and motor function. These findings demonstrate that hypoxia augments LPS-induced inflammation and induces the occurrence and development of cerebral edema in mice at high altitude. Here, we provide new information on the impact of systemic inflammation on the susceptibility to and outcomes of HACE.
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