Antioxidant evaluation of 2,4-thiazolidinedione and rhodanine derivatives

A series of derivatives of thiazolidinedione and rhodanine (TZP, RHP, RHB, MB01-MB09) were synthesized using Scheme 1 and 2. The spectral analysis of the derivatives was carried out using IR and 1HNMR techniques. The synthesized compounds were screened for their in vitro antioxidant potential. TZP, RHP and MB01 showed significant antioxidant activity which illustrates the requirement of free NH for antioxidant activity and proved unsubstituted derivatives to be more potent. MB07 and MB08 also exhibited moderate antioxidant activity and highlighted the presence of heterocyclic ring to be good for its radical scavenging activity. N-3 unsubstituted and aromatic amines substituted mannich bases were revealed to show better activity.