链条(单位)
范围(计算机科学)
基质(水族馆)
催化作用
化学
组合化学
亚甲基
计算机科学
有机化学
生态学
生物
天文
物理
程序设计语言
作者
Jesus Rodrigalvarez,Hao Wang,Rubén Martı́n
标识
DOI:10.26434/chemrxiv-2022-dc220
摘要
Herein, we disclose an interrupted deaminative Ni-catalyzed chain-walking strategy that forges sp3–sp3 architectures at remote, yet previously unfunctionalized, methylene sp3 C–H sites enabled by the presence of native amides. This protocol is characterized by its mild conditions and wide scope, including challenging substrate combinations. Site-selectivity can be dictated by a judicious choice of the ligand, thus offering an opportunity to enable sp3–sp3 bond-formations that are otherwise inaccessible in conventional chain-walking events.
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