卟啉
催化作用
电化学
锰
化学
叠氮化钠
光化学
反应性(心理学)
叠氮化物
水溶液
协调球
氢氰酸
邻接
无机化学
金属
组合化学
有机化学
电极
物理化学
替代医学
病理
医学
作者
Luiz F. T. Novaes,Yi Wang,Jinjian Liu,Xavier Riart-Ferrer,Wan-Chen Cindy Lee,Niankai Fu,Justin Ho,X. Peter Zhang,Song Lin
标识
DOI:10.1021/acscatal.2c05186
摘要
In this work, we report manganese porphyrin complexes for the electrocatalytic vicinal diazidation of alkenes with sodium azide. This protocol shows improved practicality over our previous work using MnBr2 catalysis in the following aspects: (1) it requires substantially lower catalyst loading (as low as 0.3 mol %), which reduces the formation of metal azide complexes and simplifies product purification; (2) the introduction of a neutral aqueous buffer prevents the generation of toxic hydrazoic acid, contributing to a safer experimental procedure; (3) the catalytic system displays improved reactivity toward unactivated terminal alkenes. Mechanistic studies support the roles of second-sphere hydrogen-bond donors in stabilizing key reaction intermediates.
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