细胞毒性T细胞
发酵
镰刀菌
立体化学
化学
二维核磁共振波谱
细胞毒性
IC50型
癌细胞系
生物
癌细胞
生物化学
植物
体外
癌症
遗传学
作者
Jiamei Yang,Yong-Jian Liao,Ning Chen,Lei Huang,Lizhi Zhang,Gang Du,Min Zhou
标识
DOI:10.1080/10286020.2022.2098471
摘要
Beauvercin H (1), a new cyclic hexadepsipeptide, and two known ones (2 and 3) were isolated from the EtOH extract of the solid culture of Fusarium sp. Their structures were elucidated by spectroscopic analysis, including extensive 1D and 2D NMR techniques, as well as comparison with literature values. Additionally, compounds 1-3 were tested for their cytotoxic activities. The results showed that all isolated compounds exhibited cytotoxic activities against five human cancer cell lines with IC50 values ranging from 1.379 to 13.12 μM.
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