Advances and Challenges in Molecularly Imprinted Electrochemical Sensors for Application in Environmental, Biomedicine, and Food Safety

Molecularly imprinted electrochemical sensors (MIECSs) are a specialized class of sensors based on molecularly imprinted derivative materials (MIDPs), which have been extensively applied in environmental monitoring, biomedicine, and food safety, allowing for high selectivity and sensitivity in detecting target molecules. This review provides an in-depth exploration of the most innovative and successful nanomaterials employed for modifying imprinted polymers, highlighting their crucial role in enhancing sensor performance, including carbon-based nanomaterials, meal derivatives, magnetic nanomaterials, polymeric and composite nanomaterials. In addition to reviewing advances in derivative materials design, this article delves into the current challenges facing molecularly imprinted sensors, such as issues related to template removal, nonspecific binding, and fabrication reproducibility. These challenges limit the practical application of MIECSs, particularly in complex real-world environments. The review also discusses representative applications of these sensors, including environmental monitoring, biomedicine and food safety, which demonstrate their versatility and potential. Finally, the review outlines future research directions aimed at overcoming these challenges. This includes strategies for improving the stability and reusability of MIECSs, enhancing their selectivity and sensitivity, and developing novel imprinting techniques. By addressing these issues, researchers can pave the way for the next generation of electrochemical sensors, which will be more robust, reliable, and suitable for a wide range of industrial and clinical applications.