癌症
医学
免疫疗法
癌症治疗
免疫系统
重症监护医学
肿瘤科
妇科
免疫学
内科学
作者
Halahati Tuerxun,Yixin Zhao,Yawen Li,Xingyu Liu,Shu‐Hui Wen,Jingjing Cao,Jiuwei Cui,Yuguang Zhao
标识
DOI:10.1016/j.critrevonc.2023.104064
摘要
In recent years, the indications for immunotherapy in cancer treatment have been expanding. The increased risk of cancer in young people, coupled with the fact that many women or men choose to delay childbearing, has made an increasing number of patients of childbearing age eligible for immunotherapy. Furthermore, with the improvements of various treatments, more young people and children are able to survive cancer. As a result, long-term sequelae of cancer treatments, such as reproductive dysfunction, are increasingly important for survivors. While many anti-cancer drugs are known to cause reproduction dysfunction, the effects of immune checkpoint inhibitors (ICIs) on reproduction function remain largely unknown. Through a retrospective analysis of previous reports and literature, this article aims to elucidate the causes of reproductive dysfunction induced by ICIs and focus on their specific mechanisms, in order to providing some guidance to clinicians and patients.
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