天麻素
PI3K/AKT/mTOR通路
蛋白激酶B
血管平滑肌
药理学
小桶
医学
血压
细胞生长
血管紧张素II
信号转导
化学
内科学
基因表达
生物化学
基因
平滑肌
转录组
色谱法
作者
Aling Shen,Meizhu Wu,Farman Ali,Zhi Guo,Yi Fang,Yuting Zhou,Siyu Zhang,Wenqiang Zhang,Ying Wen,Min Yu,Jun Peng,Keji Chen
标识
DOI:10.1038/s41598-023-39202-6
摘要
The effects and underlying mechanisms of gastrodin treatment on hypertensive vascular dysfunction and proliferation of vascular smooth muscle cells (VSMCs) were determined in vitro and in vivo. Using a pharmacological target network interaction analysis, 151 common targets and a PPI network were identified containing the top 10 hub genes. Kyoto encyclopedia of genes and genomes (KEGG) analysis identified the PI3K/AKT pathway as a significantly enriched pathway. Both spontaneous hypertensive rats (SHRs) and Wistar Kyoto rats were used to assess the therapeutic effects of gastrodin on hypertension. Gastrodin treatment of the SHRs resulted in a marked attenuation of elevated blood pressure, pulse wave velocity, and pathological changes in the abdominal aorta. Moreover, gastrodin treatment significantly inhibited cell growth and downregulated the expression of PCNA as well as the p-PI3K/PI3K and p-AKT/AKT levels in angiotensin II-stimulated VSMCs. Taken together, gastrodin treatment attenuates blood pressure elevation, vascular dysfunction, and proliferation of VSMCs and inhibits the activation of the PI3K/AKT pathway.
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