Developing Supramolecular Metallogel Derived from Pd2L4 Cage Molecule for Delivering an Anti‐Cancer Drug to Melanoma Cell B16−F10

Abstract Supramolecular gels are an important class of materials that are promising for its wide range of applications including drug delivery. While supramolecular gels are intrinsically porous because of the 3D nano‐matrix (gel matrix) that is being formed due to supramolecular self‐assembly process involving the gelator molecules during gelation, additional nanopores can be introduced to the overall gel if the gelator molecule itself holds molecular cavity such as metal‐organic‐cage (MOC) molecules. A MOC having the molecular formula [(Pd 2 L2 4 ).4NO 3 ].3H 2 O.2DMF.MeOH (Pd‐cage) (L2=5‐Azido‐N,N′‐di‐pyridin‐3‐yl‐isophthalamide) was successfully synthesized and characterized by FT‐IR, 1 H NMR, ESI‐MS and single crystal X‐ray diffraction. Stimuli‐reversible supramolecular metallogel PdG could easily be formed from Pd‐cage in DMSO/water mixture. The molecular cage of Pd‐cage was demonstrated to be available for loading an anti‐cancer drug namely doxorubicin (DOX). Subsequently, DOX was also loaded within PdG and delivered to melanoma cell line B16−F10 displaying significant anti‐cancer activity as revealed by both MTT and scratch assay. Rheoreversibility of PdG and its ability to load and deliver DOX to cancer cells clearly raised hope for developing this metallogel further as topical anticancer gel.